Endocrine Abstracts

Background: Previous studies suggested that treatment with somatropinum in children with GH deficiency (GHD) may alter lipid profile and pituitary–thyroid axis function. However, results are divergent and data regarding a possible association between changes of thyroid function and of circulating lipids are scarce. The aim of this study was to report the changes of the lipid profile in children with GHD treated with somatropinum and the relationship between thyroid functi...

Introduction: Both TSH and prolactin serum levels within normal range were previously reported to be associated with metabolic parameters.Aim: To analyse the connections between serum levels of prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients.Material and methods: 322 PCOS patients (mean age 24.3±5.16 years and mean BMI 28±7.57 kg/m2) with normal serum prolactin and without thyroid d...

A large body of evidence suggests that in polycystic ovary syndrome (PCOS) there is a link between abdominal adiposity, visceral adiposity dysfunction and hyperandrogenism and this relationship could be bidirectional. However a well designed study of adipose tissue distribution reported no significant differences between PCOS and controls. Visceral adiposity index (VAI) is a recently reported marker of the cardiovascular risk, strongly correlated with visceral adipose tissue (...

Background: Type 1 diabetes mellitus is frequently associated with endocrine autoimmune diseases especially thyroid disorders. These could have a negative impact on glycemic control even if there is no clinical evidence of thyroid dysfunction.The aim of the study was to evaluate thyroid function in a group of children with type 1 diabetes mellitus (T1DM) and no clinical evidence of thyroid diseases and to determine its impact on glycemic control.<p c...

The aim of the study was to evaluate the effects of hyperthyroidia on glycemic control in patients with diabetes mellitus.Research design and methods: We retrospectively evaluated the patients with diabetes and hyperthyroidism. We analysed clinical data, thyroid ultrasound exploration, laboratory analyses (glycosylated hemoglobin, free thyroxin FT4, triiodothyronine T3, thyroid stimulating hormone TSH).Results: We evaluated 48 pati...

Introduction: Insulin-like growth factor 1 (IGF-1) is an established serum marker for both diagnosis of growth hormone (GH) deficiency and for monitoring treatment with Somatropin, whether it is recommended for the classic GH-insufficient short stature cases or for other GH-sufficient disorders.Aim: To evaluate whether serum level of IGF-1 at diagnosis has a predictive value for the response to somatropin treatment during the 2 years of treatment in chil...

Introduction: Vitamin D is a hormone essential for calcium absorption and bone mineralization, which is positively associated with bone mineral density. The aim of our study was to evaluate the relationship between 25-OH vitamin D values and parameters of bone mineralization (bone mineral density - BMD) and bone quality (trabecular bone score - TBS) in patients from day to day clinical practice.Materials and methods: We evaluated 433 postmenopausal women...

Introduction: Graves’ disease is an autoimmune disease that leads to a generalized overactivity of the entire thyroid gland – hyperthyroidism. Although the link between Graves’ disease and thyroid carcinoma was widely explored, we cannot undermine the relationship between this condition and other common neoplasms.Materials and method: The retrospective analysis was performed using clinical data of 295 adult patients (225 women and 70 men) ...

Introduction: Premature pubarche is defined as early appearance of pubic or axillary hair without any other signs of puberty, before 8 years of age in girls and 9 years in boys. We present the case of a 6 months old boy who came to us with scrotal hair since birth with moderate progression until present.Case presentation: A 6 months old male patient was referred to our clinic to investigate the presence of thick scrotal hair, affirmatively present at bir...

Background: Pituitary surgery is the first treatment option for acromegaly. The reported success of pituitary surgery varies between 75 and 95% for microadenomas and 45 and 68% for macroadenomas. The aim of this study was to report our experience regarding the remission rate after pituitary surgery in acromegaly patients.Methods: This retrospective study included 70 patients diagnosed with acromegaly in our clinic between 2009 and 2016. The criteria used...